Holmium laser enucleation of the prostate improves the renal insufficiency of benign prostatic hyperplasia with hydronephrosis
Abstract
Background Hydronephrosis is a serious long-term complication of benign prostatic hyperplasia (BPH), and patients with this condition are prone to suffer from renal insufficiency. This study was performed to evaluate the efficacy of holmium laser enucleation of the prostate (HoLEP) for renal dysfunction in BPH patients with hydronephrosis. Methods In this retrospective cohort study, the enrolled 122 patients were divided into two groups according to the type of surgery: HoLEP (n=64) or bipolar plasmakinetic transurethral resection of the prostate (TURP, n=58). Perioperative indicators and follow-up variables were analysed to evaluate the efficacy and durability of HoLEP. Results The HoLEP group had a shorter operation time, bladder irrigation time, catheterization duration and hospital stays; less haemoglobin (Hb) and sodium decrease; and greater tissue removal (P<0.01). Improvements in the International Prostate Symptom Score (I-PSS), postvoid residual, maximum urinary flow rate, hydronephrosis and renal dysfunction in the HoLEP group were more evident during the entire follow-up period (P<0.01). Conclusions Therefore, by more safely and completely removing the hyperplastic prostate tissue to ensure durable relief of lower urinary tract obstruction, HoLEP can effectively and continuously benefit the recovery of renal function in BPH patients with preoperative hydronephrosis, and it is expected to become the ideal surgical intervention for these patients.
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 122 participants or records.
Read the paper
Related studies
- Treatment of non-metastatic castration-resistant prostate cancer: facing age-related comorbidities and drug–drug interactions
- The Efficacy of Flogofilm® in the Treatment of Chronic Bacterial Prostatitis as an Adjuvant to Antibiotic Therapy: A Randomized Prospective Trial
- Inhibition of growth and contraction in human prostate stromal cells by silencing of NUAK1 and -2, and by the presumed NUAK inhibitors HTH01-015 and WZ4003
- Effectiveness and Safety of a New Nutrient Fixed Combination Containing Pollen Extract Plus Teupolioside, in the Management of LUTS in Patients with Benign Prostatic Hypertrophy: A Pilot Study
- Extract from Cucurbita pepo improves BPH symptoms without affecting sexual function: a 24-month noninterventional study
- Aquablation vs. holmium laser enucleation of the prostate for benign prostatic hyperplasia: a 150-patients prospective comparative multicenter study
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.