Function-preserving plasma kinetic enucleation of the prostate with bladder neck and 12 o'clock urethral mucosal preservation for large-volume benign prostatic hyperplasia: a single-center retrospective case series
Abstract
Large-volume benign prostatic hyperplasia (BPH) poses a significant surgical challenge, as conventional transurethral resection yields suboptimal tissue removal efficiency and high rates of ejaculatory dysfunction. While endoscopic enucleation techniques (e.g., HoLEP and PKEP) offer improved efficacy, the systematic preservation of functional anatomical structures — particularly the bladder neck and anterior urethral mucosa — remains inadequately addressed in current practice.
To evaluate the safety, efficacy, and functional outcomes of function-preserving plasma kinetic enucleation of the prostate (FP-PKEP) — a modified technique incorporating systematic preservation of the bladder neck circular fibers and the 12 o'clock urethral mucosal strip — in patients with large-volume BPH.
This single-center, retrospective case series included 52 consecutive patients with large-volume BPH (prostate volume >80 mL, International Prostate Symptom Score [IPSS] > 20, maximum urinary flow rate [Qmax] < 10 mL/s) who underwent FP-PKEP between January 2025 and December 2025. The primary outcome was the change in IPSS at 3 months postoperatively; secondary outcomes included Qmax, post-void residual urine volume (PVR), quality of life (QoL) score, perioperative safety parameters, and functional preservation outcomes (urinary continence and ejaculatory function at 6 months).
All 52 patients (mean age 67.8 ± 7.2 years; mean prostate volume 93.7 ± 15.2 mL) successfully underwent FP-PKEP without…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 52 participants or records.
Read the paper
Related studies
- Treatment of non-metastatic castration-resistant prostate cancer: facing age-related comorbidities and drug–drug interactions
- The Efficacy of Flogofilm® in the Treatment of Chronic Bacterial Prostatitis as an Adjuvant to Antibiotic Therapy: A Randomized Prospective Trial
- Inhibition of growth and contraction in human prostate stromal cells by silencing of NUAK1 and -2, and by the presumed NUAK inhibitors HTH01-015 and WZ4003
- Effectiveness and Safety of a New Nutrient Fixed Combination Containing Pollen Extract Plus Teupolioside, in the Management of LUTS in Patients with Benign Prostatic Hypertrophy: A Pilot Study
- Extract from Cucurbita pepo improves BPH symptoms without affecting sexual function: a 24-month noninterventional study
- Aquablation vs. holmium laser enucleation of the prostate for benign prostatic hyperplasia: a 150-patients prospective comparative multicenter study
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.