Long-term testosterone supplementation is useful for ED with testosterone deficiency
Abstract
Dear Editor,
We present an interesting case of a patient with erectile dysfunction (ED) and testosterone deficiency (TD) who was treated with testosterone supplementation therapy (TST) in combination with sildenafil for 45 months. The patient continued to respond well even after the discontinuation of sildenafil for 8 months. Major side effects and complications were not reported at the long-term follow-up.
In September 2007, a 46-year-old, married, healthy male (height 1.75 m, weight 70 kg, BMI: 22.9, BP: 130/80 mmHg) presented to the hospital because of ED lasting more than 2 years. He reported having good erectile function prior to the development of ED. He did not experience morning or spontaneous erections and had no response to several types of phosphodiesterase-5 inhibitors (PDE5is), despite receiving a sufficient dosage of sildenafil, tadalafil, and vardenafil many times. At that time, his International Index of Erectile Function-5 (IIEF-5) score was 7 (>21 is normal), and his serum total testosterone (TT) was 9.68 nmol l−1 (2.79 ng ml−1, using a Roche electrogenerated chemiluminescence method, baseline: 2.8–8.0 ng ml−1 (9.72–27.88 nmol l−1); ng ml−1×3.47=nmol l−1). He was concerned about his ED because he had a normal libido. He was diagnosed with late-onset hypogonadism. He had normal blood glucose and triglyceride levels, no other endocrine diseases, such as thyroid or adrenal disease, normal liver and kidney function, and normal testicular size and reported no…
How strong is the evidence?
Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health. Reported size: 3,369 participants or records.
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