Pumpkin Seed Intervention to Control Diabetes Mellitus: A Systematic Review
Abstract
Background: In overcoming the problem of diabetes, developed countries have used herbal plants as an alternative treatment, considering that various types of synthetic drugs and available insulin therapy have physiological consequences in their use, such as insulin resistance, anorexia nervosa, brain atrophy, and fatty liver. Objective: This article aims to identify pumpkin seed interventions in controlling diabetes mellitus Methods: The article review was conducted using three bibliographic databases. Articles were selected based on 2011-2021 publications using the PRISMA flowchart of 2015 Results: A total of 1405 were obtained from three databases. About 17 articles according to the inclusion criteria and 7 articles were selected in this literature review. Based on the literature review results, it was found that previous researchers combined pumpkin seed with other plants to assess its efficacy in controlling blood glucose. Pumpkin seed had been tested on many experimental animals such as mice, rats, and rabbits. It showed hypoglycemic activity. Conclusion: Pumpkin seed is an herbal plant that has advantages in preventing and maintaining health as well as being used as a complementary therapy for people with diabetes mellitus
How strong is the evidence?
Evidence Hub reads this as a systematic review, done in animal, not in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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