The Study of Tadalafil and Tamsulosin as Monotherapy for Lower Urinary Tract Symptoms Due to Benign Hyperplasia of Prostate
Abstract
BACKGROUND BPH is the most common benign tumour in men and its incidence increases with age.BPH is a histological diagnosis which is identified by non-malignant hyperplasia of prostatic tissue due to smooth cell and epithelial cell proliferation.Although the current medical therapy, alpha 1 blocker alone or in combination with 5 alpha reductase inhibitors, for BPH-LUTS is effective, it has potential side effects on sexual function like retrograde ejaculation/anejaculation. BPH refers to proliferation of smooth muscle and epithelial cells within the prostate gland mainly involving transitional zone.The aim of this study is to compare Tadalafil and Tamsulosin as monotherapy in the treatment of BPH. METHODSWe analysed 60 patients of BPH (Benign Prostatic Hyperplasia) with LUTS (Lower Urinary Tract Symptoms) with baseline parameters as International Prostate Symptom Score (IPSS), QMAX (maximum urinary flow velocity), PVR (Post Voidal Residual urine volume), for a period of 6 months.They were divided in to two groups, one group receiving only alpha blockers, other group receiving only PDE -5 inhibitor (Phosphodiesterase type 5 inhibitor/PDE-5I) tadalafil in treatment of LUTS due to BPH.These patients were reviewed at 1-, 3-, 6-month intervals with the above-mentioned parameters. RESULTSOf the 60 patients taken up for the study, 30 in each group, only 55 patients completed the study.(27 patients in alpha blockers group and 28 patients in PDE-5 inhibitors group).Both groups were…
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