The impact of vitamin D and/or SAW palmetta berry extract on the spermogramm and spermatozoa functioning under the condition of experimental benign prostatic hyperplasia
Abstract
The tendency to the declining of number of spermatozoa in the ejaculate is detected in men worldwide. Benign prostatic hyperplasia (BPH) is one of the common pathology of men urogenital system. The infertility can be the consequence of this pathology. The significant number of side effects occurred during BHP medication encourages the development of new remedies for BHP prophylaxis and therapy. The laboratory animals are used in the experimental medicine with the aim to design pathological conditions. The Sulpiride model is often used for investigation of prostate gland protective activity of medicines in rats. This model’ essence lies in the prolonged sulpiride introduction which induces BPH development. The experimental and clinical investigations demonstrate questionable data as for vitamin D influence on the spermogram parameters.
Purpose. To determine the efficacy of cholecalciferol (vitamin D) administration, separately or together with Saw Palmetta berry extract, as for correction of spermogram in rats males under the condition of experimental sulpiride-induced benign prostatic hyperplasia.
Materials and methods. BPH has been modeled by intramuscular introduction of Sulpiride in dose of 40 mg/kg to 12-month rat males with body mass of 330-380 g during 30 days. The correction of BPH was carried out by vitamin D3 in dose of 4000 IU or saw Palmetta berry extract in dose of 35 mg/kg, separately or together, during 21 days after last injection of Sulpiride. Control group…
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