Pharmacological substantiation of development of suppositories with indole-3-carbinol and meloxicam for treatment of urologic diseases
Abstract
Background. Chronic abacterial prostatitis (CAP) and benign prostatic hyperplasia (BPH) are the most common urological disease in men. The results of experimental and clinical studies indicate a tight pathogenetic relationship between chronic inflammation and the development of BPH and prostate cancer. Due to the limited efficacy and adverse reactions of synthetic drugs (α-adrenoblockers, 5-α reductase inhibitors, etc.), natural herbal products, such as phytopreparations and apiary products become a viable alternative. Our research deals with pharmacological study of suppositories containing meloxicam, selective inhibitor of cyclooxygenase type 2, and indole-3-carbinol - the compound, which is found in great amounts in plants of the genus Brassica (cabbage, broccoli, radish, daikon, etc.). Methods. The specific pharmacological action of indole-3-carbinol and meloxicam (I3C+M) suppositories was studied in vivo on turpentine prostatitis model and two different models of BPH (induced by sulpiride and testosterone) in rats. Antimicrobial (antibacterial and antifungal) properties were studied in vitro. Efficacy of I3C+M suppositories was evaluated by changes in inflammatory markers, prooxidant-antioxidant status, sex hormones and prostatic-specific enzymes levels, spermogram, prostate secretion crystalogram, morphological examination of prostate tissues, and indices of fertility and sexual behavior of animals. The antimicrobial
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