Benign Prostatic Hyperplasia: Basic Research & Pathophysiology (MP06)
Abstract
METHODS: Male SD rats at 8 weeks old were used.Prostatic inflammation was induced by 5% formalin injection into ventral lobes of the prostate and saline was injected in the control group (Sham).Rats with prostatic inflammation were divided into COX-2 inhibitor (celecoxib) therapy (Treatment) and placebo groups (Placebo).Rats were treated with celecoxib at a dose of 10mg/kg daily from 2 days before induction of prostatic inflammation.Twenty-eight days later, conscious cystometry was performed to assess bladder function.After cystometry, the prostate and L6-S1 dorsal root ganglia (DRG) were excised for analysis of mRNA expression levels of IL1b and COX-2 in the prostate and a Kþ channel a-subunit, Kv1.4, in DRG as well as histological evaluation of prostate and bladder.RESULTS: In cystometry, intercontraction intervals (ICI) were significantly decreased in Placebo group compared to Sham group.mRNA expressions of IL1b and COX-2 in the prostate were significantly increased while mRNA expression of Kv1.4 in L6-S1 DRG was significantly decreased in Placebo group compared to Sham rats.However, these changes were normalized in Treatment group.Prostatic sections from Placebo group demonstrated infiltration of inflammatory cells, but not in Sham or Treatment group.There were no significant inflammatory changes in bladder sections from any groups.CONCLUSIONS: COX-2 inhibition improved not only prostatic inflammation evidenced by decreases of upregulated IL1b and COX-2 levels, but also…
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