Chrysophanic acid reduces testosterone-induced benign prostatic hyperplasia in rats by suppressing 5α-reductase and extracellular signal-regulated kinase
Abstract
// Dong-Hyun Youn 1, * , Jinbong Park 1, * , Hye-Lin Kim 2 , Yunu Jung 1 , JongWook Kang 1 , Mi-Young Jeong 2 , Gautam Sethi 3 , Kwang Seok Ahn 2 , Jae-Young Um 1, 2 1 Department of Science in Korean Medicine, Graduate School, Kyung Hee University, Dongdaemun-Gu, Seoul, 02447, Republic of Korea 2 College of Korean Medicine, Basic Research Laboratory for Comorbidity Regulation, Kyung Hee University, Dongdaemun-Gu, Seoul, 02447, Republic of Korea 3 Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 117600, Singapore * These authors have contributed equally to this work Correspondence to: Jae-Young Um, email: [email protected] Keywords: benign prostatic hyperplasia-BPH, chrysophanic acid, prostate specific antigen, 5α-reductase, extracellular signal-regulated kinase Received: April 28, 2016 Accepted: October 31, 2016 Published: November 17, 2016 ABSTRACT Benign prostatic hyperplasia (BPH) is one of the most common chronic diseases in male population, of which incidence increases gradually with age. In this study, we investigated the effect of chrysophanic acid (CA) on BPH. BPH was induced by a 4-week injection of testosterone propionate (TP). Four weeks of further injection with vehicle, TP, TP + CA, TP + finasteride was carried on. In the CA treatment group, the prostate weight was reduced and the TP-induced histological changes were restored as the normal control group. CA treatment suppressed the TP-elevated prostate specific antigen…
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