MP06-17 urinary NGF and MMP-1 levels are associated with persistence of detrusor hyperactivity in patients with benign prostatic hyperplasia after surgery
Abstract
significant increases in contraction amplitudes, non-voiding contractions (NVC), post-void residual, bladder capacity, and compliance compared to sham rats (Fig. 1A,B).Voiding efficiency (VE) was decreased in BOO rats vs. sham rats.mRNA expression levels of A2A and A3 were significantly increased, and A2B levels were significantly decreased in bladder mucosa, but not in detrusor, of BOO rats vs. controls (Fig. 1C).In comparison of A2BKO and WT rats, the NVC number was significantly increased in A2BKO rats compared to WT (Fig. 2A,B).CONCLUSIONS: These results indicate that BOO-induced bladder overactivity evident as NVC increase was associated with the reduced mucosal expression of A2B-R, and the A2B-R deletion led to bladder overactivity in male rats.Therefore, the reduction of A2B-R could be an important mechanism for the development of bladder overactivity due to BOO in male BPH patients.
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