Lifestyle habits to prevent the development of benign prostatic hyperplasia: Analysis of Japanese nationwide datasets
Abstract
Objectives Benign prostatic hyperplasia (BPH) refers to nonmalignant hyperplasia of prostate tissue, which causes lower urinary tract symptoms and has become a global public health concern in the aging population. The purpose of this study is to identify modifiable factors, which would prevent or delay BPH development. Methods The association between BPH marker drugs and climate-, socioeconomic-, health condition-, and lifestyle habits-related variables was investigated by analyzing nationwide datasets which were collected in 2018, aggregated by prefecture (administrative unit), and published by Japanese ministries. Uroselective α 1 receptor blockers and dutasteride were used as marker drugs referring to BPH prevalence. Correlation analysis, multiple linear regression analysis, and binomial logistic regression analysis were conducted with 47 Japanese prefectures as the unit. Results The variables which showed | r | > 0.5 by correlation analysis were exercise habits ( r = −0.5696), smoking habits ( r = 0.6116), and daily drinking ( r = 0.6001) for uroselective α 1 receptor blockers, and antihypertensive medication ( r = 0.5971), smoking habits ( r = 0.6598), a small amount of drinking ( r = −0.5292), and serum alanine aminotransferase ( r = 0.6814) for dutasteride. Multiple linear regression equations were constructed by including these variables ( R 2 = 0.5453 for uroselective α 1 receptor blockers and R 2 = 0.5673 for dutasteride). Binomial logistic regression analysis…
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