TERT expression in human prostate tissue reveals a potential molecular switch in benign prostatic hyperplasia progression
Abstract
Abstract Purpose Benign prostatic hyperplasia (BPH) is a leading cause of voiding symptoms in aging men. Telomerase reverse transcriptase (TERT), a key regulator of cellular senescence and tissue remodeling, has not been systematically examined in human voiding symptoms, though genome-wide association studies suggested a role in genetic and sporadic BPH. Methods Prostate tissues from patients undergoing laser enucleation for BPH were analyzed by RT-PCR. Clinical parameters were compared between TERT-positive and -negative patients. TERT expression in laser-enucleated tissues was tested for correlation with contractile smooth muscle receptors and the proliferation marker Ki67, and compared to tissues from radical prostatectomy for prostate cancer. Results In a cohort of 100 patients undergoing laser enucleation of the prostate, we detected prostatic TERT mRNA in 81% of samples. Patients with TERT-positive tissues displayed clinically relevant higher symptom scores (22.5 vs. 17.4, p = 0.0407), and more pronounced post-void residual urine (80 vs. 142 ml). Prostate volume and free PSA showed no relationship with TERT expression. TERT expression correlated with expression of α 1A -adrenoceptors ( p < 0.0001), endothelin receptor A ( p < 0.0001) and B ( p < 0.0001), thromboxane receptor ( p < 0.0001), thromboxane synthase ( p = 0.0050) and Ki67 ( p = 0.0181). TERT expression was 460-fold higher ( p = 0.0015) in laser-enucleated than in periurethral prostatectomized tissues.…
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Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 100 participants or records.
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