The Effect of Chronic Distress on the Severity of Lower Urinary Tract Symptoms in Patients with Benign Prostatic Hyperplasia (Literature review)
Abstract
The objective: to systematize current scientific data on the effect of chronic excessive stress on the severity of lower urinary tract symptoms in patients with benign prostatic hyperplasia. To determine the role of psychoemotional factors in disease progression and their impact on the effectiveness of standard therapy.
Materials and methods. An analysis was conducted of scientific publications from the past 5 years (2021–2026) indexed in the scientific databases PubMed, Scopus, Google Scholar, and Web of Science. Methods of systematic analysis were applied to the results of clinical studies investigating the neuroendocrine and immunological mechanisms underlying the relationship between the level of prolonged stress and the severity of urological symptoms.
Results. It was found that chronic distress activates the hypothalamic-pituitary-adrenal axis. This leads to hyperstimulation of the sympathetic nervous system and increased tone of alpha-1A-adrenoreceptors in the neck of the urinary bladder and prostate. Stress-induced systemic microinflammation and cytokine release act as mediators of proliferative processes in the prostate. Chronic psychoemotional stress lowers the detrusor’s sensitivity threshold, shifting the clinical picture toward pronounced irritative symptoms (nocturia, pollakisuria), which often do not correlate with prostate volume. The issue of a psychosomatic loop has been identified, in which lower urinary tract symptoms become an additional source of…
Read the paper
Related studies
- Treatment of non-metastatic castration-resistant prostate cancer: facing age-related comorbidities and drug–drug interactions
- The Efficacy of Flogofilm® in the Treatment of Chronic Bacterial Prostatitis as an Adjuvant to Antibiotic Therapy: A Randomized Prospective Trial
- Inhibition of growth and contraction in human prostate stromal cells by silencing of NUAK1 and -2, and by the presumed NUAK inhibitors HTH01-015 and WZ4003
- Effectiveness and Safety of a New Nutrient Fixed Combination Containing Pollen Extract Plus Teupolioside, in the Management of LUTS in Patients with Benign Prostatic Hypertrophy: A Pilot Study
- Extract from Cucurbita pepo improves BPH symptoms without affecting sexual function: a 24-month noninterventional study
- Aquablation vs. holmium laser enucleation of the prostate for benign prostatic hyperplasia: a 150-patients prospective comparative multicenter study
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.