Efficacy of Elaeagnus multiflora and Cynanchum wilfordii Complex Extract on Male Lower Urinary Tract Symptoms: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Abstract
Purpose Lower urinary tract symptoms (LUTS) in men substantially impair quality of life and are commonly treated with alpha-blockers or 5-alpha reductase inhibitors, which may cause adverse effects. Elaeagnus multiflora and Cynanchum wilfordii, traditional herbal remedies, have shown potential benefits in testosterone regulation and benign prostatic hyperplasia (BPH); however, clinical evidence supporting their efficacy in LUTS remains limited. This study evaluated the efficacy and safety of the E. multiflora and C. wilfordii complex (NET1701) in men with LUTS. Materials and Methods In this randomized, double-blind, placebo-controlled trial, 100 men aged 40–80 years with moderate LUTS (International Prostate Symptom Score [IPSS] 8–19) were randomized to receive NET1701 (325 mg/d) or placebo for 12 weeks. The primary outcome was the change in total IPSS from baseline to 12 weeks. Secondary outcomes included IPSS subscores, maximum urinary flow rate (Qmax), post-void residual volume (PVR), serum testosterone levels, and safety. Results At 12 weeks, the NET1701 group showed a significantly greater reduction in total IPSS compared with placebo (-5.67±3.86 vs. -1.00±4.30; p<0.0001). Significant improvements were observed in several IPSS subscores, including incomplete emptying, frequency, intermittency, and weak stream (p<0.05). Although Qmax and PVR did not differ significantly between groups, urinary symptom–related quality-of-life scores improved significantly in the NET1701…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 100 participants or records.
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