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MON-645 Metabolic Chorea: A Case Report

Miguel Walter Vasquez Cayoja, Rodny Pujalá Melero, Jhonnatan Garnica Zenteno, Jorge Zubieta Caceres

Journal of the Endocrine Society, 2025

Abstract

Abstract Disclosure: M. Vasquez Cayoja: None. R. Pujala Melero: None. J. Garnica Zenteno: None. J. Zubieta Caceres: None. Metabolic Chorea: A Case Report Introduction Hyperglycemic chorea is a rare complication in diabetic patients, associated with non-ketotic hyperglycemia, and is characterized by involuntary movements such as hemichorea or hemiballismus. It is usually accompanied by basal ganglia alterations on neuroimaging. We present the case of a 59-year-old female patient with type 2 diabetes under follow-up for 20 years and a history of hypertension, who experienced renal function deterioration leading to the modification of her treatment with NPH insulin and empagliflozin. Case Report: In November 2024, the patient presented with a two-day history of holocranial headache of mild to moderate intensity, accompanied by asthenia, adynamia, and blurred vision. Over the last 12 hours, she developed irregular, brief, bilateral involuntary movements in the upper and lower limbs and trunk, along with gait instability, prompting her admission to the emergency department. Physical examination: The patient was alert and oriented to person, place, and time, with no signs of meningeal irritation. She exhibited bilateral choreiform movements triggered by motor stimulation. Laboratory on admission: • Glucose: 339 mg/dL • Hematocrit: 30% | Hemoglobin: 10 g/dL | WBC: 8,300/mm³ (76% neutrophils) • Creatinine: 4.6 mg/dL | Urea: 160 mg/dL | ASTO Negative | Na: 135 mEq/L | K: 6.5 mEq/L |…

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