A retrospective cohort study on the improvement of urodynamic parameters and NIH-CPSI scores with Relin granules in BPH patients with high prostatitis-like symptom scores
Abstract
OBJECTIVE
To investigate the efficacy of Relin Granules combined with conventional therapy in improving urodynamic parameters, symptom scores, and inflammatory biomarkers in patients with benign prostatic hyperplasia (BPH) who have high prostatitis-like symptoms.
METHODS
This retrospective cohort study enrolled 132 BPH patients with a National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) total score ≥15 who were treated between January 2023 and January 2025. Among them, 44 patients received conventional therapy plus Relin Granules (4 g tid, 12 weeks), and 88 received conventional therapy alone. Conventional treatment included the α-blocker tamsulosin and, in some patients, the 5α-reductase inhibitor finasteride. The primary outcomes were changes in NIH-CPSI, International Prostate Symptom Score (IPSS), and urodynamic parameters.
RESULTS
After 12 weeks, the combination group showed significantly greater improvements in NIH-CPSI total score (adjusted difference -4.3, P<0.001), pain domain (-1.9, P<0.001) and quality of life domain (-1.4, P<0.001), while the urinary symptom domain did not differ significantly (P=0.056). Compared with the conventional group, the combination group had a greater reduction in IPSS total score (adjusted difference -2.1, P=0.004). No significant differences were observed in maximum flow rate (Qmax, adjusted difference 0.8 mL/s, P=0.342) or postvoid residual volume (PVR, 3.2 mL, P=0.415). The combination group showed significantly…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 132 participants or records.
Read the paper
Related studies
- Treatment of non-metastatic castration-resistant prostate cancer: facing age-related comorbidities and drug–drug interactions
- The Efficacy of Flogofilm® in the Treatment of Chronic Bacterial Prostatitis as an Adjuvant to Antibiotic Therapy: A Randomized Prospective Trial
- Inhibition of growth and contraction in human prostate stromal cells by silencing of NUAK1 and -2, and by the presumed NUAK inhibitors HTH01-015 and WZ4003
- Effectiveness and Safety of a New Nutrient Fixed Combination Containing Pollen Extract Plus Teupolioside, in the Management of LUTS in Patients with Benign Prostatic Hypertrophy: A Pilot Study
- Extract from Cucurbita pepo improves BPH symptoms without affecting sexual function: a 24-month noninterventional study
- Aquablation vs. holmium laser enucleation of the prostate for benign prostatic hyperplasia: a 150-patients prospective comparative multicenter study
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.