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Potassium-competitive acid blockers: Clinical pearls and practical insights

Hisham Wehbe, Claire Beveridge

Cleveland Clinic Journal of Medicine, 2026

Abstract

Potassium-competitive acid blockers (P-CABs) are a new class of acid-suppressing drugs; to date, only one of them (vonoprazan) has been approved for use in the United States. The authors of this article review how P-CABs (and vonoprazan in particular) differ from proton pump inhibitors (PPIs), evidence supporting their effectiveness, indications for vonoprazan, and ongoing and future studies.

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