Efficacy of early prone position for COVID-19 patients with severe hypoxia: a single-center prospective cohort study
Abstract
Dear Editor, With the global epidemic of COVID-19, as of July 8, 2020, 12,025,348 people have been infected with 4.56% mortality [1]. Many COVID-19 patients died due to severe hypoxia [2, 3]. It is particularly important to find a simple and effective way for COVID-19 patients’ treatment. Recent studies reported that prone position was used to treat non-intubated COVID-19 patients and hypoxemic acute respiratory failure [4, 5]. However, the number of patients was small, the follow-up was short, clinical outcomes were not assessed in their study. In this study, we aimed to explore whether the early prone position can effectively improve severe hypoxia, CT imaging performance and survival prognosis of COVID-19 patients with severe hypoxia. A total of 60 COVID-19 patients with severe hypoxia were enrolled from February 1, 2020 to April 30, 2020 (Fig. S1, Tables S1 and S2) (Chinese Clinical Trial Registry: ChiCTR2000033053). And 23 patients were taken early prone position and 37 patients were not. In prone position group, the pulse oxygen saturation (SpO2) increased from 91.09 ± 1.54% to 95.30 ± 1.72% (P < 0.01) after 10 min, 95.48 ± 1.73% after 30 min (P < 0.01), but no significant difference after 30 min compared with 10 min (P = 0.58) (Fig. 1a). The respiratory rate (RR) decreased from 28.22 ± 3.06 times/min to 27.78 ± 2.75 times/min after 10 min (P = 0.20), 24.87 ± 1.84 times/ min after 30 min (P < 0.01), but no significant difference after 10 min compared with the baseline…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 12,025,348 participants or records.
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