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SAT-541 Empagliflozin Induced Acute Pancreatitis

Harshita Marasandra Ramesh, Tehseen Hammad, Sundas Zahra, Julia Ma, Violeta Zeykan

Journal of the Endocrine Society, 2025

Abstract

Abstract Disclosure: H. Marasandra Ramesh: None. T. Hammad: None. S. Zahra: None. J. Ma: None. V. Zeykan: None. Introduction: Empagliflozin is a sodium-glucose co-transporter inhibitor used in the treatment of type 2 diabetes mellitus. They effectively decrease blood glucose levels by reducing renal reabsorption of glucose. Common adverse effects associated with it are urinary tract infections, and genitourinary fungal infections. Here, we report a case of empagliflozin- induced pancreatitis as a rare side effect. Case presentation: A 65-year-old male with a past medical history of type 2 diabetes mellitus on metformin, insulin lispro and glargine, empagliflozin, gastroesophageal reflux, hypertension, presented to the hospital with chief complaints of epigastric pain for 2 weeks associated with diarrhea. Detailed medication reconciliation history was relevant for initiation of empagliflozin 3 months prior to the presentation. The epigastric pain was 8/10 in intensity at times, radiating to the back and occasionally waking him up from sleep. He also had a couple of episodes of diarrhea in 1 week. He endorsed having decreased appetite and had lost about 40 lbs in the last 4 months. He had chronic symptoms of reflux which worsened in the last one week. Social history negative for smoking and alcohol intake. Physical examination pertinent for epigastric tenderness and groin fungal infection. Labs revealed mildly elevated lipase levels of 84 U/L, normal liver function tests,…

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