Green chemistry approaches in the analytical validation of fosravuconazole using UV spectrophotometry and HPLC
Abstract
• This study addresses the need for a precise quantitative method to determine Fosravuconazole and developed validated analytical methods using UV spectrophotometry and High-Performance Liquid Chromatography (HPLC). • Both methods were rigorously validated according to ICH Q2(R1) guidelines, demonstrating their suitability for the assessment of individual substances in various mixtures. • The UV Spectrophotometric method is simpler, faster, and more environmentally friendly, as evidenced by its higher AGREE score and lower environmental impact compared to the RP-HPLC method. • The BAGI score for the proposed UV and RP-HPLC method of Fosravuconazole is 82.5 and 72.5 respectively, concluding that the UV/RP-HPLC method is more practically feasible for industries. • By adopting these sustainable approaches, researchers contribute to fostering a more environmentally conscious and sustainable scientific community. Fosravuconazole, a newly developed oral antifungal medication by Eisai, has been utilized since 2018 for the treatment of tinea unguium. Its notable characteristics include high oral absorption and systemic bioavailability, which allow for a brief treatment duration of 3 months. Its mild inhibition of the cytochrome P450 enzyme, which plays a role in adverse effects during polypharmacy, allows for the safe use of fosravuconazole alongside other medications, making it suitable for elderly patients. This study addresses the need for a precise quantitative method to…
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