Omadacycline vs. Moxifloxacin for Community-Acquired Pneumonia: A Real-World Retrospective Comparative Effectiveness and Safety Study
Abstract
Abstract Background This retrospective study aimed to compare the real-world clinical effectiveness and safety of omadacycline versus moxifloxacin in treating adult patients with CAP. Methods This single-center, retrospective cohort study was conducted at the First Affiliated Hospital of Guangxi University of Science and Technology. A total of 348 adult inpatients diagnosed with CAP between June 2022 and December 2024 were enrolled and divided into an Omadacycline group (n = 170) and a Moxifloxacin group (n = 178). The primary outcome was early clinical response (ECR), assessed 72–120 hours after treatment initiation. Secondary outcomes included overall clinical response rate, bacterial eradication rate, changes in inflammatory biomarkers, and adverse events.. Results Baseline characteristics were comparable between the two groups. The ECR success rate was 92.9% (158/170) in the Omadacycline group and 91.0% (162/178) in the Moxifloxacin group (absolute risk difference: 1.9%, 95% CI: -4.1% to 7.9%; p = 0.508), demonstrating the non-inferior efficacy of omadacycline. Overall clinical response (92.9% vs. 91.0%, p = 0.508) and bacterial eradication rates (88.2% vs. 86.8%, p = 0.776) were also similar. Both groups showed significant and comparable improvements in inflammatory markers and pneumonia severity scores post-treatment. However, the overall incidence of adverse events was significantly lower in the Omadacycline group (15.3% vs. 30.3%, p
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 178 participants or records.
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