Drugs in tuberculosis and leprosy
Abstract
This chapter contains adverse drug events and reactions attributed to antituberculosis and antileprosy drugs published between January and December 2020. The results of several observational studies comparing shorter regimen vs standard therapy are described. The incidence of and risk factors for serious adverse events associated with pyrazinamide are investigated in an observational study. The safety of moxifloxacin-based regimen for treating drug-resistant TB is evaluated in a systematic review. The safety of isoniazid for TB prevention in pregnant and postpartum women is systematically evaluated in a review that includes 40 studies. The safety of antibiotic regimen for the treatment of paucibacillary and multibacillary leprosy compared to other available regimens has been assessed in a systematic review. Two matched case-control studies, respectively, investigate the association of genetic polymorphism and ABO blood group with the risk or severity of drug-induced hepatotoxicity. The range of cutaneous adverse drug reactions attributed to ethambutol is examined in a retrospective study. The risk factors influencing hepatotoxicity attributed to antituberculous drugs is investigated. The predictors for adverse events in patients on dialysis is explored. Circulatory failure attributed to rifampicin is reported. The first report of fatality with off-label use of clofazimine is described. Cases of lichenoid and psoriasiform drug eruptions attributed to rifampicin are described.…
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