Quality control testing with method development and validation of moxifloxacin
Abstract
Moxifloxacin is a fourth-generation fluoroquinolone antibiotic extensively used for the treatment of respiratory tract infections, skin infections, intra-abdominal infections, and ocular bacterial infections due to its broad-spectrum antibacterial action. This is due to the fact that the fact that there are dependable analytical analytical analytical analytical quality. Because of its superior sensitivity, selectivity, repeatability, and accuracy, High-Performance Liquid Chromatography (HPLC), especially Reverse Phase-HPLC (RP-HPLC), has emerged as the preferred analytical method. In order to obtain sufficient separation with acceptable system suitability parameters, the creation of an HPLC method entails the methodical adjustment of chromatographic conditions such as column selection, mobile phase composition, pH, flow rate, wavelength, and sample preparation. Following development, the analytical method must be validated according to International Council for Harmonisation (ICH) guidelines to demonstrate its fitness for routine pharmaceutical analysis. Several validated HPLC methods for moxifloxacin have been reported for pharmaceutical dosage forms, biological fluids, and stability studies, confirming the reliability of HPLC for quality control and regulatory compliance. This article summarizes the current approaches to HPLC method development and validation for moxifloxacin and highlights critical analytical considerations for obtaining robust and reproducible…
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