Amelioration of Moxifloxacin-Induced Hepatotoxicity in Rats by Vitamin C and L-Carnitine
Abstract
Background: Moxifloxacin, a widely used fluoroquinolone antibiotic effective against a range of bacterial infections, has been associated with potential hepatotoxicity, a significant clinical concern that can limit its use. The underlying mechanism is strongly linked to oxidative stress. This study investigates the ameliorative effects of two well-known antioxidants, Vitamin C and L-Carnitine, against moxifloxacin-induced liver damage in adult male albino rats, aiming to identify potential and accessible strategies to mitigate these adverse effects. Methods: Forty adult male albino rats were systematically divided into four experimental groups (n=10): a control group receiving normal saline, a group receiving moxifloxacin (80 mg/kg), a group receiving moxifloxacin with Vitamin C (500 mg/kg), and a group receiving moxifloxacin with L-Carnitine (600 mg/kg). The treatments were administered daily for a period of 30 days. Finally, at the end of the study, the quantitative measurement of serum levels of major liver enzymes (Aspartate Aminotransferase - AST, Alanine Aminotransferase - ALT, Alkaline Phosphatase - ALP) and total serum bilirubin (TSB) was done. Liver tissues were also excised, processed, and subjected to close examination of the histopathological changes with attention being put to the degree of tissue cellular and architectural damage. Results: The moxifloxacin-treated group showed a statistically significant (p≤0.05) and marked increase in serum AST, ALT, ALP, and…
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