Comparative efficacy of intracameral 0.5% moxifloxacin versus 0.1% cefuroxime in preventing postoperative endophthalmitis following phacoemulsification cataract surgery: a randomized controlled trial
Abstract
Background: Postoperative endophthalmitis is an uncommon but vision-threatening complication of cataract surgery that can result in serious ocular morbidity if not prevented or treated promptly. Intracameral antibiotic prophylaxis has become an important preventive strategy in modern phacoemulsification surgery. Cefuroxime and moxifloxacin are commonly used agents, but comparative local evidence remains limited. This study was conducted to compare their prophylactic efficacy in preventing postoperative endophthalmitis after cataract surgery.
Objective: To compare the efficacy of intracameral 0.5% moxifloxacin and intracameral 0.1% cefuroxime in preventing postoperative endophthalmitis following phacoemulsification cataract surgery.
Methods: This randomized controlled trial was conducted at the Institute of Ophthalmology, Mayo Hospital, Lahore, over six months from 27 June 2022 to 27 December 2022. A total of 60 patients aged 50–70 years undergoing phacoemulsification cataract surgery were enrolled through non-probability consecutive sampling and randomly allocated into two equal groups by lottery method. Group A received intracameral cefuroxime 1 mg in 0.1 mL saline, while Group B received intracameral moxifloxacin 100 µg in 0.1 mL saline at the end of surgery. Patients were followed for six weeks postoperatively to assess prophylactic efficacy. Data were analyzed using SPSS version 25, with p≤0.05 considered statistically significant.
Results: The mean age was 60.13 ± 5.84…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 60 participants or records.
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