Exploring the clinical characteristics and etiological diagnosis of Chlamydia psittaci pneumonia confirmed by targeted next-generation sequencing: A retrospective observational study
Abstract
Chlamydia psittaci (C psittaci) is an important causative agent of community-acquired pneumonia (CAP). However, conventional pathogen detection methods are often ineffective in the early diagnosis of CAP, making C psittaci pneumonia challenging to detect. C psittaci ranges from mild, self-limited to acute respiratory failure, and the early identification of this disease can be challenging. Targeted next-generation sequencing (tNGS) of bronchoalveolar lavage fluid has the potential to improve the pathogen identification in C psittaci pneumonia. This retrospective study aims to systematically evaluate the clinical characteristics and etiological diagnostic value of tNGS in patients with C psittaci pneumonia, providing further insights into the diagnosis and management of this disease. We performed a retrospective analysis of samples obtained from 40 patients diagnosed with C psittaci pneumonia using tNGS at Zhengzhou People's Hospital between January 2024 and March 2025. The clinical characteristics, laboratory findings, radiological features, and treatment strategies for each patient were systematically evaluated. The analysis revealed that C psittaci pneumonia was frequently associated with avian or poultry exposure. Predominant clinical manifestations included fever, cough, sputum production, headache, and fatigue. Laboratory tests commonly indicated elevated neutrophil percentage, C-reactive protein, procalcitonin, and interleukin-6 levels, alongside reduced median…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 40 participants or records.
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