Nontuberculosis Mycobacterial Infections: A Series of 14 Cases from a Tertiary Care Center in Türkiye
Abstract
Objectives: Nontuberculous mycobacteria (NTM) are emerging opportunistic pathogens with an increasing global incidence. However, epidemiological data and treatment outcomes remain limited in Türkiye. This study aimed to evaluate the clinical characteristics, species distribution, and treatment outcomes of NTM infections in a tertiary center in Türkiye.
Materials and methods: A retrospective analysis was conducted of patients diagnosed with NTM infection between 2021 and 2025 in the Department of Infectious Diseases and Clinical Microbiology. The diagnosis was established according to the American Thoracic Society/Infectious Diseases Society of America (ATS/IDSA) criteria. Demographic characteristics, risk factors, radiological findings, microbiological profiles, antimicrobial susceptibility patterns, treatment regimens, and clinical outcomes were analyzed.
Results: Fourteen patients were included in the study. The mean age was 50.1 ± 13.8 years, and nine patients were male. Underlying risk factors were present in eight patients, including human immunodeficiency virus (HIV) infection (n = 4), malignancy (n = 3), bronchiectasis (n = 1), and chronic obstructive pulmonary disease (COPD) (n = 1). The most frequently identified species were Mycobacterium kansasii (n = 5) and Mycobacterium abscessus (n = 5), followed by Mycobacterium avium, Mycobacterium simiae, Mycobacterium gordonae, and Mycobacterium lentiflavum (n = 1 each). Pulmonary involvement was observed in 10 patients,…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 13 participants or records.
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