Exploring the inhibitory performance of expired moxifloxacin and norfloxacin on copper corrosion in saline environment
Abstract
The reuse of expired drugs has become a challenge to maintain environmental clean-liness and achieve economic benefit. In this report, two expired drugs, moxifloxacin and norfloxacin, were used as inhibitors for copper corrosion in 3.5 % NaCl solution at different temperatures using several experimental approaches including chemical, electrochemical and spectroscopic techniques. The interaction of these two molecules on the copper surface was also inspected using different adsorption models. Using a dose of 500 mg L-1 of these drugs at 298 K, maximum inhibition efficiencies (IE) of 88.7 and 85.2 % were estimated from the potentiodynamic polarization technique for Mox and Nor, respectively., confirming that they can be considered as promising and effective inhibitors. The IE values were enhanced with increasing drugs doses and reduced with rising temperature. The higher IE is due to the strong adsorption of these molecules on the copper surface and such adsorption is physical in nature and follows the Langmuir adsorption isotherm. This is due to their unique chemical structures as they contain a number of functional groups. Polarization experiments confirmed that the drugs were tuned to behave as mixed-type inhibitors with an anodic predominance. All thermos¬dynamic and kinetic parameters were calculated and discussed in details, and the inhibition mechanism is proposed. All experimental results obtained by different techniques were in agreement with each other.
Read the paper
Related studies
- Synthesis, In Vitro and In Silico Molecular Docking Studies of Novel Phthalimide–Pyrimidine Hybrid Analogues to Thalidomide as Potent Antitubercular Agents
- Molecular investigation of antimicrobial peptides against Helicobacter pylori proteins using a peptide-protein docking approach
- Screening of novel narrow-spectrum benzofuroxan derivatives for the treatment of multidrug-resistant tuberculosis through in silico, in vitro, and in vivo approaches
- Synthesis, Characterization, Anticancer, Antioxidant, and In Silico Evaluation of Semicarbazides and Thiosemicarbazides
- Fast and accurate prediction of drug induced proarrhythmic risk with sex specific cardiac emulators
- In-silico screening of marine fungal metabolites identifies potential FtsZ inhibitors against MDR-tuberculosis through docking and molecular dynamics analysis
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.