Clinical Characteristics of 40 Cases of Chlamydia Psittaci Pneumonia Confirmed by Metagenomic Next-Generation Sequencing
Abstract
Background: Chlamydia psittaci pneumonia is an underrecognized zoonotic infection with potentially severe outcomes, and its clinical features in the context of metagenomic next-generation sequencing (mNGS)-based diagnosis warrant systematic characterization. This study aimed to describe the clinical, laboratory, imaging, and bronchoscopic characteristics of mNGS-confirmed C. psittaci pneumonia and to explore features associated with severe community-acquired pneumonia (SCAP).
Methods: We conducted a single-center retrospective study analyzing clinical data from 40 patients with community-acquired pneumonia (CAP) caused by C. psittaci, diagnosed via mNGS at the First Affiliated Hospital of Guangxi Medical University from September 2019 to September 2024. General information, clinical symptoms, laboratory findings, imaging features, treatment, and prognosis were reviewed. Continuous variables were compared using Student's t-test or Mann-Whitney U-test as appropriate; categorical variables were compared using chi-square or Fisher's exact test.
Results: All 40 patients had a clear history of poultry exposure. Among them, 13 cases (32.5%) were classified as severe CAP (SCAP), and 27 were non-SCAP. SCAP patients more frequently exhibited high fever, dyspnea, and extrapulmonary manifestations, with severe hypoxia. The most common chest CT findings were pulmonary consolidation, air bronchograms, and infiltrative shadows. Bronchoscopy revealed congestion and edema in 75% of patients,…
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