Prospective study of moxifloxacin in 106 patients with community-acquired pneumonia
Abstract
AIM: To study the clinical application of moxifloxacin in treatment of community-acquired pneumonia(CAP). METHODS: A Prospective design was conducted, 220 adult patients with CAP were radomly divided into two study groups treated with moxifloxacin and two control groups treated with others antibiotics according to the severity of illness. The 106 patients in study groups were treated with moxifloxacin 0.4-0.8 g, po, qd for 10 d. In control groups, 44 patients with mild CAP were treated with clalithromycin 0.5 g, po, bid for 14 d or ceforuxime injection 2.5 g, iv, gtt, bid for 10 d; 70 patients with moderate CAP were treated with ceforuxime injection 2.5 g, iv, gtt, bid for 10 d, cefaropatone injection 3.0 g, iv,gtt, bid for 10 d or ampicillin/sobatan injection 3.0 g, iv,gtt, bid for 10 d. Statistical difference was analyzed in terms of effectiveness, side effects and compliance among the groups. RESULTS: The total cured rate of two study groups were 95 % and 85 %, respectively; while those of two control groups were 95 % and 86 %, respectively; resulting in no significant difference (P0.05)(95 % vs 95 %, 85 % vs 86 %), but the difference in cured rates on d 3 and d 5 were significant (P0.01, P0.05) among the groups. The clinical sign and symptom such as fever, cough and chest pain in treated groups were alleviated earlier than in the control groups(P0.01, P0.05). A few side effects caused by moxifloxacin were recorded during the period of treatment. Specific pathogens of CAP…
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