Epidemiology, changing resistance trends and serotypes of Streptococcus pneumoniae in children in Chongqing, China, 2019-2024: a multicenter study
Abstract
OBJECTIVE: To investigate the clinical characteristics, temporal trends in antimicrobial resistance, and distribution of bacterial serotypes of Streptococcus pneumoniae (S. pneumoniae)in children in Chongqing region from 2019 to 2024.
METHODS: S. pneumoniae isolates and corresponding epidemiological data were collected from multi-center laboratories. Antimicrobial susceptibility testing was performed in the central research laboratory for each study period from 2019 to 2024, and the results were interpreted according to the breakpoint criteria specified in the Clinical and Laboratory Standards Institute (CLSI) M100-S34 guidelines (2024 edition). Capsular serotyping of S. pneumoniae was performed using the capsular swelling test, and vaccine coverage rate were calculated.
RESULTS: A total of 17,180 S. pneumoniae isolates were isolated over six years, accounting for 17.2% of all clinically isolated pathogenic bacteria and 45.9% of all Gram-positive bacteria. The isolates were mainly obtained from respiratory tract specimens (97.9%), followed by blood specimens (1.1%). S. pneumoniae was predominantly isolated from preschool, toddler and Infants, with isolation rates of 32.5%, 30.5% and 25.9%, respectively, together accounting for 88.8% of all S. pneumoniae isolates. The detection rates of penicillin-susceptible S. pneumoniae (PSSP), penicillin-intermediate S. pneumoniae (PISP), and penicillin-resistant S. pneumoniae (PRSP) were 83.7% (14196/16964), 14.8% (2513/16964), and 1.5%…
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