Evidence Hub

The critical role of 16S rRNA sequencing in diagnosis and management of an odontogenic deep neck abscess: A case report

Ghiotti A, Monticelli J, Busetti M, Maglione M, Di Bella S, Barbone F, Koncan R

IDCases, 2026

Abstract

Odontogenic abscesses are characteristically polymicrobial infections where fastidious anaerobes play a critical role. Conventional culture methods often fail to identify these pathogens, leading to diagnostic and therapeutic challenges. We present a case of a severe deep neck and metastatic lung abscess following third molar extraction. While the initial culture of the abscess drainage was deceiving, 16S rRNA sequencing revealed the infection's real anaerobic nature. Therapy was successfully targeted, leading to full clinical resolution. This case highlights the limitations of culture methods and the importance of molecular diagnosis in guiding optimal management of complicated odontogenic infections.

How strong is the evidence?

Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.

How the five levels of evidence work. The level is assigned automatically from the abstract and can be wrong, so check the paper.

Read the paper

Related studies

Go deeper in Evidence Hub

Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.

Open this study Sign up free