Natural products as efflux pump inhibitors enhancing the antibacterial efficacy of quinolones
Abstract
Antimicrobial resistance is a global pandemic and one of the biggest public health challenges. Efflux pumps are one of several antimicrobial resistance mechanisms. Efflux pumps are proteins that act by efflux or pumping substances out of cells. The major efflux pumps in bacteria include the ATP-binding cassette (ABC) Superfamily, Small Multidrug Resistance Family (SMR), Major FacilitatorSuperfamily (MFS), Multidrug and Toxic Compound Extrusion Family (MATE), and Resistance Nodulation Cell Division (RND). Quinolones are antimicrobials that inhibit DNA synthesis by inhibiting type IV topoisomerase and DNA gyrase of bacteria. Efflux-mediated quinolone resistance can happen by the overexpression of some efflux pump genes in the prokaryotes. The substrate for most of the efflux pumps is fluoroquinolones like ciprofloxacin and Norfloxacin. A novel strategy to combat antimicrobial resistance is by the use of efflux pump inhibitors which can effectively block the efflux pumps. Plant-derived phytochemicals are promising lead molecules in developing an efflux pump inhibiting drug and thereby combat quinolone mediated efflux resistance. This review discusses plant-derived EPIs that can be used to combat quinolone-resistant microorganisms.
Read the paper
Related studies
- Structural and topological analysis of thiosemicarbazone-based metal complexes: computational and experimental study of bacterial biofilm inhibition and antioxidant activity
- Toward better cures for Mycobacterium abscessus lung disease
- Challenges for global antibiotic regimen planning and establishing antimicrobial resistance targets: implications for the WHO Essential Medicines List and AWaRe antibiotic book dosing
- Design, Synthesis and In vitro Antitubercular Effect of New Chalcone Derivatives Coupled with 1,2,3‐Triazoles: A Computational Docking Techniques
- Upregulation of pmrA, pmrB, pmrC, phoQ, phoP, and arnT genes contributing to resistance to colistin in superbug Klebsiella pneumoniae isolates from human clinical samples in Tehran, Iran
- Whole-genome sequencing of clinical isolates of Citrobacter Europaeus in China carrying blaOXA−48 and blaNDM−1
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.