Surveillance of antimicrobial resistant pathogens in Canadian retail meat using a One-Health lens: linkages to the human sector through the farm-to-fork continuum
Abstract
Antimicrobial resistance (AMR) remains a pressing public health issue and has been emphasized in Canadian and global public health priorities. AMR pathogens have arisen and spread across clinical, animal, and environmental sectors, which together can be studied using a One-Health perspective. Using this framework, the farm-to-fork continuum links agri-food and human clinical sectors, where AMR pathogens may spread to humans through the exposure and consumption of retail meat. Beyond foodborne pathogens, retail meat has been noted as a source of AMR pathogens often associated with the nosocomial environment; however, linkages to human clinical infections typically rely on traditional typing methods. This study reports a low prevalence of Clostridioides difficile (0.9%, 3/318), methicillin-resistant Staphylococcus aureus (MRSA) (0.9%, 3/318), and varying prevalences of carbapenemase-producing (CP) organisms (Acinetobacter spp.: 4.1%, 13/318; Pseudomonas spp.: 4.1%, 13/317; Aeromonas spp.: 59.8%, 189/316) from retail meat samples collected through the Canadian Integrated Program for Antimicrobial Resistance Surveillance (CIPARS). When available, whole genome sequencing was used to evaluate genomic linkages between retail meat and human clinical infections collected through the Canadian Nosocomial Infection Surveillance Program (CNISP) or the Canadian Ward Study (CANWARD). Comparisons were performed with C. difficile, MRSA, and CP-Acinetobacter spp., where retail meat isolates…
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