Comparison of the Effects of Solifenacin Succinate for the Treatment of Overactive Bladder with Extended Release Tolterodine
Abstract
Objective: To compare the therapeutic effects of solifenacin succinate with extended release tolterodine for the treatment of overactive bladder (OAB) in Bangladeshi patients. Methods: A prospective, randomized, single-blind, two-arm, parallel-group, clinical trial was conducted in the department of Urology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka from January 2013 to June 2014. A total of 65 patients with OAB were treated with solifenacin succinate 5 mg (experimental group, n=33) and extended release tolterodine 4 mg (control group, n=32), both at night daily for 12 weeks. Efficacy and safety variables were assessed and compared with baseline and at 12 weeks treatment in between the two groups. Results: At week 12, solifenacin succinate and extended release tolterodine demonstrated reduction in the mean number of micturition (50% vs. 51%), urgency (87% vs. 73%), urge incontinence (89% vs. 71%), nocturia (89% vs. 74%), usage of pads (90% vs. 71%) per 24 hours. There was increased in the mean voided volume of each micturition in both the groups without any difference in between them. The incidence of major adverse events were dry mouth (15.2% vs. 9.4%), constipation (9.1% vs. 15.6%), and blurred vision (6.1% vs. 3.1%) respectively. Conclusions: Solifenacin succinate had greater efficacy to extended release tolterodine in treating overactive bladder. There were no significant treatment difference between the two groups in decreasing the number of micturition…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 65 participants or records.
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