Dose Pattern Evolution and Therapeutic Benefit in Patients on Solifenacin or Fesoterodine Treatment in Daily Clinical Practice
Abstract
Aim: To explore in daily clinical practice
the evolution in time of the fesoterodine and solifenacin dose pattern and
assess the therapeutic benefit provided by the highest dose of these anti-muscarinics.
Patients and Methods: This was a post-hoc analysis of data from an
observational, cross-sectional, retrospective and multicenter study. Adult
patients diagnosed with over active bladder (OAB) who initiated fesoterodine or
solifenacin treatment were included. Data on the prescribed treatment and dose,
change of dose, reasons for switching and treatment benefit were recorded.
Results: A total of 828 subjects were analyzed (262 receiving solifenacin and
566 fesoterodine). Most subjects were women with a mean time since diagnosis of
more than one year and aged around 60 years old. The majority of patients
initiated the OAB treatment with the lowest available dose (64% fesoterodine
vs. 77% solifenacin). At the follow-up visit 54% of the fesoterodine group and
66% of the solifenacin opted for dose escalation. At the study visit, 70.1%
fesoterodine vs. 43.3% solifenacin remained on the highest dose. A
significantly greater proportion of subjects receiving fesoterodine 8 mg,
reported higher improvement in terms of both patient-reported-treatment benefit
and clinical global impression compared with solifenacin 10 mg (p < 0.05).
Conclusion: In routine clinical practice more than half of the patients opted
for the higher dose and remained on it over time, suggesting a desire for…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 828 participants or records.
Read the paper
Related studies
- Sarcopenia, sarcopenic overweight/obesity and risk of cardiovascular disease and cardiac arrhythmia: A cross-sectional study
- Workplace Violence Is Associated With Impaired Work Functioning in Nurses: An Italian Cross-Sectional Study
- Vagus Nerve Dysfunction in the Post-COVID-19 Condition: a pilot cross sectional study
- Association Between Metabolic Associated Fatty Liver Disease and Chronic Kidney Disease: A Cross-Sectional Study from NHANES 2017–2018
- Efficacy and safety of solifenacin succinate 10 mg once Daily: A multicenter, phase III, randomized, double-blind, placebo-controlled, parallel-group trial in patients with overactive bladder
- Association between triglyceride glucose‐body mass index and hypertension in Chinese adults: A cross‐sectional study
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.