Comparison of solifenacin versus mirabegron in women with overactive bladder presenting at a tertiary care hospital
Abstract
Background: Overactive bladder (OAB) is a common and distressing syndrome characterized by urinary urgency, frequency, nocturia, and urgency incontinence in the absence of urinary tract infection or other pathology. It significantly impacts physical comfort, emotional well-being, and social functioning. Pharmacologic management primarily involves antimuscarinic agents and β3-adrenergic receptor agonists, with Mirabegron offering comparable efficacy but a more favorable side-effect profile compared to antimuscarinics. Objective: To evaluate and compare the therapeutic efficacy and tolerability of Solifenacin and Mirabegron in women with overactive bladder. Methods: This comparative cross-sectional study was conducted at Chandka Medical Hospital between March and August 2025. A total of 161 female patients aged 18 years and above with OAB symptoms persisting for over three months were enrolled. Group A received Solifenacin 10 mg daily, and Group B received Mirabegron 25 mg daily. The duration of therapy was three weeks, after which symptom improvement was evaluated based on the number of micturition episodes, urgency episodes, and incontinence per 24 hours. Data were analyzed using SPSS version 20, with p < 0.05 considered statistically significant. Results: The mean age of participants was 41.8 ± 7.56 years. The mean duration of OAB symptoms was 4.6 ± 0.91 months. Baseline mean values included 9.2 ± 2.1 micturitions, 6.6 ± 1.3 urgency episodes, and 5.1 ± 1.51 incontinence…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 161 participants or records.
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