Expert perspectives on the effectiveness and combination strategies of mirabegron in the management of overactive bladder
Abstract
Objective: To assess treatment preferences, effectiveness, and safety of mirabegron in overactive bladder (OAB), and to assess its role as monotherapy or in combination therapy in improving outcomes. Methods: The nationwide cross-sectional survey was conducted among clinicians in India using a 22-item questionnaire to assess treatment preferences, effectiveness, and safety of mirabegron in OAB. The survey evaluated symptom control, clinician preferences, and combination use. Participation was voluntary, and informed consent was obtained. Data were analyzed descriptively using frequencies and percentages and presented in tables and figures. Results: A total of 133 clinicians participated in the survey. A substantial proportion (79.7%) preferred mirabegron as the treatment of choice for managing OAB. Around 68% of participants considered the safety profile as the key factor when prescribing mirabegron for patients with OAB. Additionally, 55% of clinicians observed a significant reduction in micturition frequency in patients treated with mirabegron. Many clinicians (69.92%) reported that increased adverse effects are the primary reason for discontinuation of anticholinergic therapy in their practice. A majority (87.22%) favored mirabegron for patients who are non-responsive to or unsuitable for anticholinergics. About 71% indicated that severity of symptoms is the main factor influencing the initiation of combination therapy with mirabegron and solifenacin in OAB patients.…
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Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause.
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