Modern Management of Neurogenic Bladder
Abstract
Abstract Purpose of Review The purpose of this review is to highlight contemporary changes in the management of pediatric neurogenic bladder, using spina bifida as the reference population. Advances in early diagnosis, pharmacotherapy, and surveillance strategies have altered traditional treatment paradigms, with a growing emphasis on bladder preservation and prevention of upper urinary tract deterioration. Recent Findings Recent literature demonstrates an increased reliance on medical management as first-line therapy. Anticholinergic agents remain the cornerstone of treatment, with expanding use of beta-3 adrenergic agonists as adjuncts or alternatives. Intradetrusor onabotulinumtoxinA has emerged as an effective option for refractory detrusor overactivity, offering improved bladder compliance and continence outcomes. While these strategies may delay or reduce the need for surgical reconstruction, their long-term impact on rates and timing of lower urinary tract reconstruction remains unclear and warrants ongoing investigation. Summary Multiple clinical guidelines now support structured, proactive management incorporating early clean intermittent catheterization, pharmacologic therapy and routine urinary tract surveillance. Imaging and urodynamics play a critical role in monitoring renal health and bladder dynamics. However, there remains uncertainty regarding the optimal protocol for longitudinal follow-up, including frequency and modality of evaluation. Future research…
Read the paper
Related studies
- Sarcopenia, sarcopenic overweight/obesity and risk of cardiovascular disease and cardiac arrhythmia: A cross-sectional study
- Workplace Violence Is Associated With Impaired Work Functioning in Nurses: An Italian Cross-Sectional Study
- Vagus Nerve Dysfunction in the Post-COVID-19 Condition: a pilot cross sectional study
- Association Between Metabolic Associated Fatty Liver Disease and Chronic Kidney Disease: A Cross-Sectional Study from NHANES 2017–2018
- Efficacy and safety of solifenacin succinate 10 mg once Daily: A multicenter, phase III, randomized, double-blind, placebo-controlled, parallel-group trial in patients with overactive bladder
- Association between triglyceride glucose‐body mass index and hypertension in Chinese adults: A cross‐sectional study
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.