Editorial Comment to Efficacy of mirabegron, a β3‐adrenoreceptor agonist, in Japanese women with overactive bladder and either urgency urinary incontinence or mixed urinary incontinence: Post‐hoc analysis of pooled data from two randomized, placebo‐controlled, double‐blind studies
Abstract
placebo-controlled trial of flexible-dose fesoterodine in subjects with overactive bladder. Urology 2010; 75: 62–8. 17 Herschorn S, Swift S, Guan Z et al. Comparison of fesoterodine and tolterodine extended release for the treatment of overactive bladder: a head-to-head placebo-controlled trial. BJU Int. 2010; 105: 58–66. 18 Kamei J, Furuta A, Akiyama Y et al. Video-urodynamic effects of mirabegron, a b3 -adrenoceptor agonist, in patients with low-compliance bladder. Int. J. Urol. 2015; 22: 956–61. 19 Matsukawa Y, Takai S, Funahashi Y, Yamamoto T, Gotoh M. Urodynamic evaluation of the efficacy of mirabegron on storage and voiding functions in women with overactive bladder. Urology 2015; 85: 786–90. 20 Shi H, Chen H, Zhang Y, Cui Y. The efficacy and safety of vibegron in treating overactive bladder: a systematic review and pooled analysis of randomized controlled trials. Neurourol. Urodyn. 2020; 39: 1255–63. 21 Yoshida M, Takeda M, Gotoh M et al. Efficacy of vibegron, a novel b3adrenoreceptor agonist, on severe urgency urinary incontinence related to overactive bladder: post hoc analysis of a randomized, placebo-controlled, double-blind, comparative phase 3 study. BJU Int. 2020; 125: 709–17. 22 Kelleher C, Cardozo L, Kobashi K, Lucente V. Solifenacin: as effective in mixed urinary incontinence as in urge urinary incontinence. Int. Urogynecol. J. Pelvic Floor Dysfunct. 2006; 17: 382–8. 23 Uemura S, Homma Y. Reliability and validity of King’s Health Questionnaire in patients…
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Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
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