Home Monitoring in Patients with Idiopathic Pulmonary Fibrosis: A Randomized Controlled Trial
Abstract
RATIONALE
Idiopathic pulmonary fibrosis (IPF) is a deadly disease with increasingly impaired health-related quality of life (HRQOL). EHealth technologies facilitate collection of physiological outcomes and patient reported-outcomes (PROMs) at home, but randomized controlled trials (RCTs) on the effects of eHealth are scarce. We investigated whether a home monitoring program improved HRQOL and medication use for IPF patients.
METHODS
We performed a multicenter RCT in newly treated patients with IPF. Patients were randomly assigned to standard care or a home monitoring program on top of standard care for 24 weeks. The home monitoring program included home spirometry, reporting of symptoms and side-effects, PROMs, information, a medication coach and eConsultations. The primary endpoint was between-group difference in change in Kings Brief Interstitial Lung disease (K-BILD) questionnaire score at 24 weeks.
RESULTS
90 patients were randomized (46 patients home monitoring, 44 standard care). After 24 weeks, no statistically significant differences were found in K-BILD total score (home monitoring group:+2.7 points, standard care:+0.03, p=0.24) and psychological domain score (home monitoring group:+5.1, standard care:-0.5, p=0.1). In the home monitoring group medication was more often adjusted (1 vs 0.3 adjustments per patient, p=0.027). Patient satisfaction with the home monitoring program was high. Home-based spirometry was highly correlated with hospital-based spirometry over…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 90 participants or records.
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