Re: Identification and Local Delivery of Vasodilators for the Reduction of Ureteral Contractions
Abstract
available at https://pubmed.ncbi.nlm.nih.gov/31792422/ Editorial Comment: The current study identifies therapeutic agents that can be locally delivered, resulting in significant decreases in the frequency and amplitude of ureteral contractions compared to placebo and standard oral therapy (tamsulosin). These findings have implications for treatment of patients with ureteral colic, ureteral stents and ureteral stones, and those who have undergone surgery for ureteral stones. A theoretical advantage of local therapies is that they are applied directly to the target tissue, allowing for higher local effective doses of drugs to be used that could not be reached when administered orally, while the risk of systemic side effects is considerably reduced. Therefore, application of local relaxants to the ureter has the potential to create a greater therapeutic effect than the current standard of care a blockers as local therapy can be applied in doses greater than 10,000 times those of the threshold of tolerance for oral medications. Anthony Atala, MD Suggested Reading Danuser H, Weiss R, Abel D et al: Systemic and topical drug administration in the pig ureter: effect of phosphodiesterase inhibitors alpha1, beta and beta2adrenergic receptor agonists and antagonists on the frequency and amplitude of ureteral contractions. J Urol 2001; 166: 714. Voiding Function and Dysfunction, Bladder Physiology and Pharmacology, and Female Urology Re: Safety and Efficacy of Mirabegron: Analysis of a…
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Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 11,261 participants or records.
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