Translational Perspectives on Binge-Eating: Insights from Animal Models
Abstract
PURPOSE OF REVIEW: Binge-eating is a behavior that is both recognized in both binge-eating disorder and binge-subtypes of restrictive eating disorders. Binge-eating is distinct from obesity, although the two frequently co-occur. The purpose of this review is to examine animal models of binge like behavior independent of obesity as a phenotype and to examine recent findings. RECENT FINDINGS: Current research indicates three major precipitants of binge-like behavior in rodents, namely limited access to palatable food, limited access to food following stress, and cue-induced overconsumption. These models have enabled mechanistic studies, which highlight the role of several key brain regions and circuits in binge-eating. Taken together, these studies highlight the important role that preclinical models play in elucidating the mechanisms underlying binge-eating and to develop therapeutic interventions.
How strong is the evidence?
Evidence Hub reads this as a review, done in animal, not in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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