Resting-state functional magnetic resonance imaging alterations in borderline personality disorder: A systematic review
Abstract
BACKGROUND
Borderline personality disorder (BPD) is a severe psychiatric disorder characterized by emotion dysregulation, impulsivity, and interpersonal disturbances. Several structural and functional neuroimaging abnormalities have been described in BPD. In particular, resting-state functional magnetic resonance imaging (rs-fMRI) studies have recently suggested various connectivity disturbances within and between brain networks in BPD. This review aimed at providing an updated summary of the evidence reported by the available rs-fMRI studies in BPD individuals.
METHODS
A search on PubMed, Scopus, and Web of Science was performed to identify rs-fMRI alterations in BPD. A total of fifteen studies met our inclusion criteria.
RESULTS
Overall, aberrant resting-state functional connectivity (rs-FC) within and between default mode network (DMN), salience network (SN), and central executive network (CEN) were observed in BPD compared to healthy controls, as well as selective FC impairments in bilateral amygdala, anterior and posterior cingulate cortex, hippocampus, and prefrontal cortex.
LIMITATIONS
The observational design, small sample size, non-balance gender group, high rates of concurrent comorbidities and medications, and heterogeneity across imaging methodologies limit the generalizability of the results.
CONCLUSIONS
The identification of altered patterns of rs-FC within and between selective brain networks, including DMN, SN, and CEN, could further our knowledge of the…
How strong is the evidence?
Evidence Hub reads this as a systematic review. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
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