Comparison of Outcomes of Dialectical Behavior Therapy (DBT) Alone versus DBT Combined with Second-Generation Antipsychotic in the Treatment of Borderline Personality Disorder
Abstract
Background: Borderline Personality Disorder (BPD) is a complex psychiatric condition characterized by emotional instability, impulsivity, self-harming behaviors, and difficulties in interpersonal relationships. While Dialectical Behavior Therapy (DBT) is widely recognized as the most effective treatment for BPD, some individuals continue to struggle with severe mood disturbances and impulsive behaviors, necessitating additional therapeutic interventions. This study aimed to compare the outcomes of DBT alone versus DBT combined with second-generation antipsychotic medication (olanzapine) in the treatment of BPD. Methodology: A randomized controlled trial was conducted at Gulab Devi Hospital, Lahore, where 102 participants diagnosed with BPD, as per DSM-5 criteria, were recruited and assigned to one of two treatment groups. Group A received DBT alone, while Group B received DBT along with olanzapine (5-20 mg/day). Treatment effectiveness was assessed using standardized clinical scales, including the Hamilton Depression Rating Scale (HAM-D), Hamilton Anxiety Rating Scale (HARS), and Barratt Impulsiveness Scale (BIS-11). Additionally, self-harm attempts and emergency unit visits were recorded over a 12-week period. Result: The results indicated that both groups showed significant symptom reduction; however, the DBT + Olanzapine group demonstrated greater improvements across all measured outcomes. Participants in the combination therapy group exhibited significantly lower…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 102 participants or records.
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