Highlights of Cardiovascular Disease Prevention Studies Presented at the 2025 European Society of Cardiology Conference
Abstract
PURPOSE OF REVIEW: This review summarizes key findings from cardiovascular disease prevention studies presented at the 2025 European Society of Cardiology (ESC) Conference. It highlights trials on novel therapies, vaccination, blood pressure management, and the use of technology and risk scores to guide treatment.
RECENT FINDINGS: The CONFIDENCE trial showed that a combination of finerenone and empagliflozin significantly reduced the urine albumin-creatinine ratio in patients with type 2 diabetes mellitus and chronic kidney disease. The DANFLU-2 trial found that the high-dose influenza vaccine was associated with fewer cardio-respiratory hospitalizations in older adults compared to the standard dose. The RETREAT FRAIL trial demonstrated that tapering antihypertensive medications in frail, elderly patients safely reduced pill burden without increasing all-cause mortality and adverse cardiovascular (CV) and non-CV outcomes. In diagnostics, the AI-Gatekeeper trial showed an AI tool reduced unnecessary advanced imaging for coronary artery disease (CAD) by 76%, lowering costs without compromising safety. The CAC CV-PREVITAL trial found that adding a coronary artery calcium score to standard risk assessment improved blood pressure control. The REBOOT-CNIC trial challenged a paradigm, showing that beta-blockers provided no significant benefit in post-myocardial infarction patients without reduced ejection fraction. A Post hoc analysis of SURMOUNT-5 found that tirzepatide offers a…
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