Patient-oriented approach to prescribing systemic therapy for psoriasis with biologics: a case report
Abstract
In recent decades, for the treatment of patients with moderate to severe psoriasis, biologics have been actively developed, the use of which is recommended when the psoriasis systemic treatment is insufficiently effective or if there are contraindications to it. However, in recent years, experts have increasingly raised the question of the use of biologics at an early stage of the aggressive course of the disease, especially in cases where psoriasis causes significant psychosocial maladjustment in the patient, problems with establishing interpersonal and social relationships, a feeling of stigmatization and a decrease in the quality of work. Palmoplantar psoriasis which is associated with great difficulties in daily and occupational life requires special attention in this regard. The article presents a case report that shows of the successful early use of therapy with biologics in a patient to relieve symptoms of palmoplantar psoriasis and distal interphalangeal psoriatic arthritis which began in the early stages of the disease due to a significant decrease in the quality of life and work activity, as well as of an emphatic refusal of systemic basic therapy with methotrexate. After a 4-week initial course of secukinumab, almost complete regression of psoriatic eruptions and symptoms of psoriatic arthritis was noted. The patient’s psychoemotional state has stabilized. Performing manipulations related to one’s occupational duties does not cause any difficulties due to the…
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Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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