PM540. Differential changes on the white matter brain network in ultra-high risk for psychosis and first-episode psychosis
Abstract
encodes an activator protein of D-amino acid oxidase (DAAO), a D-serine degrading enzyme, has been reported to associate with schizophrenia and bipolar disorders. To further elucidate the relationship between D-serine metabolism and psychiatric dis-orders, we presently examined by an ELISA technique the con-tents of G72 protein in plasma and CSF of Japanese patients with schizophrenia, MDD, and healthy controls. Neither plasma nor CSF G72 protein levels differ among the three diagnostic groups and relate with age of the participants in each group. These data do not support the previously observed distinct expression in plasma or CSF G72 protein levels in schizophrenia. On the other hand, we found a significant positive correlation between plasma G72 protein levels and the positive score (P=0.027, r=0.43) of the Positive and Negative Syndrome Scale (PANSS), but not the PANSS negative, general psychopathology or total scores, in the patients with schizophrenia. The CSF G72 protein levels did not significantly correlate with each of the four PANSS scores. In MDD, there was no significant association of either of plasma or CSF G72 levels with depression severity scores. To obtain an insight into the significance of the above correlation in schizophrenia, further studies to clarify the molecular and cellular mechanisms and extrinsic factors of the control of G72 expression are required. Abstract Background: Developmental process of dysconnectivity dur-ing transition into…
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