Alterations in adult behavior as a result of early life manipulations
Abstract
Approximately 20% of people experience at least one depressive episode during their lifetime.Furthermore, a majority of these individuals do not experience full remission of symptoms following current treatment protocols.Drug development has been slow, as the etiology of mood disorders is multifactorial and poorly understood; individual susceptibility is influenced by complex gene-environment interactions.Stress is often reported to precede or exacerbate depressive illness, and is therefore used to model depressive-like symptomatology in laboratory animals.While existing paradigms have been useful, few take into account the cumulative effects of genetics and/or experiences that underlie stress-sensitivity.Naturalistic paradigms that utilize multiple risk factors may better model the development of affective disorders.Ucn urocortin VBS visible burrow syste 1 Chapter 1. Introduction and general background
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