Left ventricular mass predicts cardiac reverse remodelling in patients treated with empagliflozin
Abstract
Background The cardiovascular (CV) benefits of sodium-glucose transport protein 2 inhibitors have been attributed, in part, to cardiac reverse remodelling. The EMPA-HEART CardioLink-6 study reported that sodium-glucose cotransporter-2 inhibition for 6 months with empagliflozin was associated with a significant reduction in left ventricular mass indexed to body surface area (LVMi). In this sub-analysis, we evaluated whether baseline LVMi may influence how empagliflozin affects cardiac reverse remodelling. Methods A total of 97 patients with type 2 diabetes and coronary artery disease were randomized to empagliflozin (10 mg/d) or matching placebo for 6 months. The study cohort was divided into those whose baseline LVMi was ≤ 60 g/m^2 and those who had a baseline LVMi > 60 g/m^2. Subgroup comparisons were conducted using a linear regression model adjusted for baseline values (ANCOVA) that included an interaction term between LVMi subgroup and treatment. Results Baseline LVMi was 53.3 g/m^2 (49.2–57.2) and 69.7 g/m^2 (64.2–76.1) for those with baseline ≤ 60 g/m^2 (n = 54) and LVMi > 60 g/m^2 (n = 43) respectively. The adjusted difference of LVMi regression between those randomized to empagliflozin and placebo were − 0.46 g/m^2 (95% CI: −3.44, 2.52, p = 0.76) in the baseline LVMi ≤ 60 g/m^2 subgroup and − 7.26 g/m^2 (95% CI: −11.40, −3.12, p = 0.0011) in the baseline LVMi > 60 g/m^2 subgroup ( p -for-interaction = 0.007). No significant associations were found between baseline…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 97 participants or records.
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